the Berghuis Laboratory

at McGill University, Montreal

Protein Expression and Purification

Incubator shakers (including refrigerated shakers)

Various centrifuges

Gravity and high-pressure protein chromatography equipment, including:

Äkta Explorer

Äkta Purifier

Äkta Prime

 

Protein Crystallization

Temperature controlled crystallization cabinets

Sparse matrix crystallization screens covering >300 distinct solution conditions

Microscopes and integrated CCD imaging system

Dynamic light scattering instrument

Crystallization robot

 

Macromolecular X-ray Diffraction Facilities

Rapid access to synchrotron radiation

Rigaku Rotating Anode generator

Osmic multilayer confocal optics

Raxis IV++ area detector

Cryocrystallography capabilities

 

Computational Resources

SGI workstations (O2, Octane)

Dual-processor LINUX workstations

Dual-processor Mac OS X workstations

PC’s for lab use

 

Software Resources and Bioinformatics Tools

All major software programs for macromolecular crystallographic computing

Several docking programs

Several small compound libraries for virtual screening (over 150,000 compounds)