the Berghuis Laboratory

at McGill University, Montreal

1. Hickey DR, Berghuis AM, Lafond G, Jaeger JA, Cardillo TS, McLendon D, et al. Enhanced thermodynamic stabilities of yeast Iso-1-cytochromes C with amino acid replacements at positions 52 and 102. Journal of Biological Chemistry. 1991;266(18):11686-94.

 

2. Berghuis AM, Brayer GD. Oxidation state-dependent conformational changes in cytochrome c. Journal of Molecular Biology. 1992;223(4):959-76.

 

3. Langen R, Brayer GD, Berghuis AM, McLendon G, Sherman F, Warshel A. Effect of the Asn52 → Ile mutation on the redox potential of yeast cytochrome c. Theory and experiment. Journal of Molecular Biology. 1992;224(3):589-600.

 

4. Sixma TK, Pronk SE, Kalk KH, Van Zanten BAM, Berghuis AM, Hol WGJ. Lactose binding to heat-labile enterotoxin revealed by X-ray crystallography. Nature. 1992;355(6360):561-4.

 

5. Burk D, Wang Y, Dombroski D, Berghuis AM, Evans SV, Luo Y, et al. Isolation, crystallization and preliminary diffraction analyses of human pancreatic α-amylase. Journal of Molecular Biology. 1993;230(3):1084-5.

 

6. Berghuis AM, Guillemette JG, McLendon G, Sherman F, Smith M, Brayer GD. The role of a conserved internal water molecule and its associated hydrogen bond network in cytochrfome c. Journal of Molecular Biology. 1994;236(3):786-99.

 

7. Berghuis AM, Guillemette JG, Smith M, Brayer GD. Mutation of tyrosine-67 to phenylalanine in cytochrome c significantly alters the local heme environment. Journal of Molecular Biology. 1994;235(4):1326-41.

 

8. Coleman DE, Berghuis AM, Lee E, Linder ME, Gilman AG, Sprang SR. Structures of active conformations of Giα1 and the mechanism of GTP hydrolysis. Science. 1994;265(5177):1405-12.

 

9. Coleman DE, Lee E, Mixon MB, Linder ME, Berghuis AM, Gilman AG, et al. Crystallization and preliminary crystallographic studies of Giα1 and mutants of Giα1 in the GTP and GDP-bound states. Journal of Molecular Biology. 1994;238(4):630-4.

 

10. Tong H, Berghuis AM, Chen J, Luo Y, Guss JM, Freeman HC, et al. ASIR: An automatic procedure for determining solvent structure in protein crystallography. Journal of Applied Crystallography. 1994;27(3 pt 3):421-6.

 

11. Mixon MB, Lee E, Coleman DE, Berghuis AM, Gilman AG, Sprang SR. Tertiary and quaternary structural changes in Giα1 induced by GTP hydrolysis. Science. 1995;270(5238):954-60.

 

12. Sutton RB, Davletov BA, Berghuis AM, Sudhof TC, Sprang SR. Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold. Cell. 1995;80(6):929-38.

 

13. Berghuis AM, Lee E, Raw AS, Gilman AG, Sprang SR. Structure of the GDP-Pi complex of Gly203→Ala G(iα1): A mimic of the ternary product complex of Gα-catalyzed GTP hydrolysis. Structure. 1996;4(11):1277-90.

 

14. Marc Lett C, Berghuis AM, Frey HE, Lepock JR, Guillemette JG. The role of a conserved water molecule in the redox-dependent thermal stability of iso-1-cytochrome c. Journal of Biological Chemistry. 1996;271(46):29088-93.

 

15. Rafferty SP, Guillemette JG, Berghuis AM, Smith M, Brayer GD, Mauk AG. Mechanistic and structural contributions of critical surface and internal residues to cytochrome c electron transfer reactivity. Biochemistry. 1996;35(33):10784-92.

 

16. Hon WC, McKay GA, Thompson PR, Sweet RM, Yang DSC, Wright GD, et al. Structure of an enzyme required for aminoglycoside antibiotic resistance reveals homology to eukaryotic protein kinases. Cell. 1997;89(6):887-95.

 

17. Berghuis AM. Crystallization and preliminary X-ray diffraction studies of homoserine dehydrogenase from Saccharomyces cerevisiae. Acta Crystallographica Section D: Biological Crystallography. 1998;54(3):413-5.

 

18. Hunt JF, Mixon MB, Berghuis AM. AUTO_XPL: A Unix shell-script system to sequence X-PLOR refinement runs. Journal of Applied Crystallography. 1998;31(3):491-5.

 

19. Wright GD, Berghuis AM, Mobashery S. Aminoglycoside antibiotics: Structures, functions, and resistance. Advances in Experimental Medicine and Biology1998. p. 27-69.

 

20. Thompson PR, Schwartzenhauer J, Hughes DW, Berghuis AM, Wright GD. The COOH terminus of aminoglycoside phosphotransferase (3')-IIIa is critical for antibiotic recognition and resistance. Journal of Biological Chemistry. 1999;274(43):30697-706.

 

21. Wybenga-Groot LE, Draker KA, Wright GD, Berghuis AM. Crystal structure of an aminoglycoside 6'-N-acetyltransferase: Defining the GCN5-related N-acetyltransferase superfamily fold. Structure. 1999;7(5):497-507.

 

22. DeLaBarre B, Thompson PR, Wright GD, Berghuis AM. Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases. Nature Structural Biology. 2000;7(3):238-49.

 

23. Burk DL, Hon WC, Leung AKW, Berghuis AM. Structural analyses of nucleotide binding to an aminoglycoside phosphotransferase. Biochemistry. 2001;40(30):8756-64.

 

24. Leung AKW, Duewel HS, Honek JF, Berghuis AM. Crystal structure of the lytic transglycosylase from bacteriophage lambda in complex with hexa-N-acetylchitohexaose. Biochemistry. 2001;40(19):5665-73.

 

25. Yim VCN, Zolli M, Badurina DS, Rossi L, Brown ED, Berghuis AM. Crystallization and preliminary X-ray diffraction studies of glycerol 3-phosphate cytidylyltransferase from Staphylococcus aureus. Acta Crystallographica Section D: Biological Crystallography. 2001;57(6):918-20.

 

26. Burk DL, Berghuis AM. Protein kinase inhibitors and antibiotic resistance. Pharmacology and Therapeutics. 2002;93(2-3):283-92.

 

27. Daigle DM, Rossi L, Berghuis AM, Aravind L, Koonin EV, Brown ED. YjeQ, an essential, conserved, uncharacterized protein from Escherichia coli, is an unusual GTPase with circularly permuted G-motifs and marked burst kinetics. Biochemistry. 2002;41(37):11109-17.

 

28. Fong DH, Berghuis AM. Substrate promiscuity of an aminoglycoside antibiotic resistance enzyme via target mimicry. EMBO Journal. 2002;21(10):2323-31.

 

29. Thompson PR, Boehr DD, Berghuis AM, Wright GD. Mechanism of aminoglycoside antibiotic kinase APH(3')-IIIa: role of the nucleotide positioning loop. Biochemistry. 2002 Jun 4;41(22):7001-7. PubMed PMID: 12033933. Epub 2002/05/30. eng.

 

30. Burk DL, Ghuman N, Wybenga-Groot LE, Berghuis AM. X-ray structure of the AAC(6')-Ii antibiotic resistance enzyme at 1.8 A resolution; examination of oligomeric arrangements in GNAT superfamily members. Protein science : a publication of the Protein Society. 2003 Mar;12(3):426-37. PubMed PMID: 12592013. Pubmed Central PMCID: PMC2312454. Epub 2003/02/20. eng.

 

31. Jacques SL, Mirza IA, Ejim L, Koteva K, Hughes DW, Green K, et al. Enzyme-assisted suicide: Molecular basis for the antifungal activity of 5-hydroxy-4-oxonorvaline by potent inhibition of homoserine dehydrogenase. Chemistry and Biology. 2003;10(10):989-95.

 

32. Ejim L, Mirza IA, Capone C, Nazi I, Jenkins S, Chee GL, et al. New phenolic inhibitors of yeast homoserine dehydrogenase. Bioorganic and Medicinal Chemistry. 2004;12(14):3825-30.

 

33. Fong DH, Berghuis AM. Crystallization and preliminary crystallographic analysis of 3'-aminoglycoside kinase type IIIa complexed with a eukaryotic protein kinase inhibitor, CKI-7. Acta crystallographica Section D, Biological crystallography. 2004 Oct;60(Pt 10):1897-9. PubMed PMID: 15388945. Epub 2004/09/25. eng.

 

34. Ishiyama N, Creuzenet C, Lam JS, Berghuis AM. Crystal structure of WbpP, a genuine UDP-N-acetylglucosamine 4-epimerase from Pseudomonas aeruginosa: Substrate specificity in UDP-hexose 4-epimerases. Journal of Biological Chemistry. 2004;279(21):22635-42.

 

35. Bernatchez S, Szymanski CM, Ishiyama N, Li J, Jarrell HC, Lau PC, et al. A single bifunctional UDP-GlcNAc/Glc 4-epimerase supports the synthesis of three cell surface glycoconjugates in Campylobacter jejuni. Journal of Biological Chemistry. 2005;280(6):4792-802.

 

36. Burk DL, Xiong B, Breitbach C, Berghuis AM. Structures of aminoglycoside acetyltransferase AAC(6')-Ii in a novel crystal form: structural and normal-mode analyses. Acta crystallographica Section D, Biological crystallography. 2005 Sep;61(Pt 9):1273-9. PubMed PMID: 16131761. Epub 2005/09/01. eng.

 

37. Christensen KE, Mirza IA, Berghuis AM, MacKenzie RE. Magnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase. Journal of Biological Chemistry. 2005;280(40):34316-23.

 

38. Demendi M, Ishiyama N, Lam JS, Berghuis AM, Creuzenet C. Towards a better understanding of the substrate specificity of the UDP-N-acetylglucosamine C4 epimerase WbpP. Biochemical Journal. 2005;389(1):173-80.

 

39. Fong DH, Burk DL, Berghuis AM. Aminoglycoside kinases and antibiotic resistance. Handbook of Experimental Pharmacology2005. p. 157-88.

 

40. Gao F, Yan X, Baettig OM, Berghuis AM, Auclair K. Regio- and chemoselective 6'-N-derivatization of aminoglycosides: bisubstrate inhibitors as probes to study aminoglycoside 6'-N-acetyltransferases. Angewandte Chemie (International ed in English). 2005 Oct 28;44(42):6859-62. PubMed PMID: 16206301. Epub 2005/10/06. eng.

 

41. Lemke CT, Hwang J, Xiong B, Cianciotto NP, Berghuis AM. Crystallization and preliminary crystallographic analysis of an aminoglycoside kinase from Legionella pneumophila. Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 2005;61(6):606-8.

 

42. Mirza IA, Nazi I, Korczynska M, Wright GD, Berghuis AM. Crystal structure of homoserine transacetylase from Haemophilus influenzae reveals a new family of alpha/beta-hydrolases. Biochemistry. 2005 Dec 6;44(48):15768-73. PubMed PMID: 16313180. Epub 2005/11/30. eng.

 

43. Fong DH, Yim VC, D'Elia MA, Brown ED, Berghuis AM. Crystal structure of CTP:glycerol-3-phosphate cytidylyltransferase from Staphylococcus aureus: examination of structural basis for kinetic mechanism. Biochimica et biophysica acta. 2006 Jan;1764(1):63-9. PubMed PMID: 16344011. Epub 2005/12/14. eng.

 

44. Gao F, Yan X, Shakya T, Baettig OM, Ait-Mohand-Brunet S, Berghuis AM, et al. Synthesis and structure-activity relationships of truncated bisubstrate inhibitors of aminoglycoside 6'-N-acetyltransferases. J Med Chem. 2006 Aug 24;49(17):5273-81. PubMed PMID: 16913716. Epub 2006/08/18. eng.

 

45. Ishiyama N, Creuzenet C, Miller WL, Demendi M, Anderson EM, Harauz G, et al. Structural studies of FlaA1 from Helicobacter pylori reveal the mechanism for inverting 4,6-dehydratase activity. Journal of Biological Chemistry. 2006;281(34):24489-95.

 

46. Nascimento M, Zhang WW, Ghosh A, Houston DR, Berghuis AM, Olivier M, et al. Identification and characterization of a protein-tyrosine phosphatase in Leishmania: Involvement in virulence. Journal of Biological Chemistry. 2006;281(47):36257-68.

 

47. Burk DL, Hwang J, Kwok E, Marrone L, Goodfellow V, Dmitrienko GI, et al. Structural Studies of the Final Enzyme in the α-Aminoadipate Pathway-Saccharopine Dehydrogenase from Saccharomyces cerevisiae. Journal of Molecular Biology. 2007;373(3):745-54.

 

48. Korczynska M, Mukhtar TA, Wright GD, Berghuis AM. Structural basis for streptogramin B resistance in Staphylococcus aureus by virginiamycin B lyase. Proceedings of the National Academy of Sciences of the United States of America. 2007;104(25):10388-93.

 

49. Miller WL, Matewish MJ, McNally DJ, Ishiyama N, Anderson EM, Brewer D, et al. Flagellin glycosylation in Pseudomonas aeruginosa PAK requires the O-antigen biosynthesis enzyme WbpO. Journal of Biological Chemistry. 2008;283(6):3507-18.

 

50. Xiong B, Burk DL, Shen J, Luo X, Liu H, Shen J, et al. The type IA topoisomerase catalytic cycle: A normal mode analysis and molecular dynamics simulation. Proteins: Structure, Function and Genetics. 2008;71(4):1984-94.

 

51. Fong DH, Berghuis AM. Structural basis of APH(3')-IIIa-mediated resistance to N1-substituted aminoglycoside antibiotics. Antimicrob Agents Chemother. 2009 Jul;53(7):3049-55. PubMed PMID: 19433564. Pubmed Central PMCID: PMC2704631. Epub 2009/05/13. eng.

 

52. Matte A, Kozlov G, Trempe JF, Currie MA, Burk D, Jia Z, et al. Preparation and characterization of bacterial protein complexes for structural analysis. Advances in protein chemistry and structural biology. 2009;76:1-42. PubMed PMID: 20663477. Epub 2009/01/01. eng.

 

53. Mirza IA, Yachnin BJ, Wang S, Grosse S, Bergeron H, Imura A, et al. Crystal structures of cyclohexanone monooxygenase reveal complex domain movements and a sliding cofactor. J Am Chem Soc. 2009 Jul 1;131(25):8848-54. PubMed PMID: 19385644. Epub 2009/04/24. eng.

 

54. Rodionov D, Romero PA, Berghuis AM, Herscovics A. Expression and purification of recombinant M-Pol I from Saccharomyces cerevisiae with alpha-1,6 mannosylpolymerase activity. Protein expression and purification. 2009 Jul;66(1):1-6. PubMed PMID: 19249370. Epub 2009/03/03. eng.

 

55. Volpato JP, Yachnin BJ, Blanchet J, Guerrero V, Poulin L, Fossati E, et al. Multiple conformers in active site of human dihydrofolate reductase F31R/Q35E double mutant suggest structural basis for methotrexate resistance. Journal of Biological Chemistry. 2009;284(30):20079-89.

 

56. Fong DH, Lemke CT, Hwang J, Xiong B, Berghuis AM. Structure of the antibiotic resistance factor spectinomycin phosphotransferase from Legionella pneumophila. Journal of Biological Chemistry. 2010;285(13):9545-55.

 

57. Gomez MA, Alisaraie L, Shio MT, Berghuis AM, Lebrun C, Gautier-Luneau I, et al. Protein tyrosine phosphatases are regulated by mononuclear iron dicitrate. Journal of Biological Chemistry. 2010;285(32):24620-8.

 

58. Lau PCK, Leisch H, Yachnin BJ, Mirza IA, Berghuis AM, Iwaki H, et al. Sustained development in baeyer-villiger biooxidation technology. ACS Symposium Series2010. p. 343-72.

 

59. Fong DH, Xiong B, Hwang J, Berghuis AM. Crystal structures of two aminoglycoside kinases bound with a Eukaryotic protein kinase inhibitor. PLoS ONE. 2011;6(5).

 

60. Freiburger LA, Baettig OM, Sprules T, Berghuis AM, Auclair K, Mittermaier AK. Competing allosteric mechanisms modulate substrate binding in a dimeric enzyme. Nature Structural and Molecular Biology. 2011;18(3):288-94.

 

61. Hambleton S, Salem S, Bustamante J, Bigley V, Boisson-Dupuis S, Azevedo J, et al. IRF8 mutations and human dendritic-cell immunodeficiency. New England Journal of Medicine. 2011;365(2):127-38.

 

62. Shi K, Houston DR, Berghuis AM. Crystal structures of antibiotic-bound complexes of aminoglycoside 2''-phosphotransferase IVa highlight the diversity in substrate binding modes among aminoglycoside kinases. Biochemistry. 2011 Jul 19;50(28):6237-44. PubMed PMID: 21678960. Epub 2011/06/18. eng.

 

63. Yachnin BJ, Colin DY, Volpato JP, Ebert M, Pelletier JN, Berghuis AM. Novel crystallization conditions for tandem variant R67 DHFR yield a wild-type crystal structure. Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 2011;67(11):1316-22.

 

64. Zhang Z, Mui MZ, Chan F, Roopchand DE, Marcellus RC, Blanchette P, et al. Genetic analysis of B55alpha/Cdc55 protein phosphatase 2A subunits: association with the adenovirus E4orf4 protein. Journal of virology. 2011 Jan;85(1):286-95. PubMed PMID: 21047956. Pubmed Central PMCID: PMC3014202. Epub 2010/11/05. eng.

 

65. Caldwell SJ, Berghuis AM. Small-angle X-ray scattering analysis of the bifunctional antibiotic resistance enzyme aminoglycoside (6') acetyltransferase-ie/aminoglycoside (2'') phosphotransferase-ia reveals a rigid solution structure. Antimicrob Agents Chemother. 2012 Apr;56(4):1899-906. PubMed PMID: 22290965. Pubmed Central PMCID: PMC3318351. Epub 2012/02/01. eng.

 

66. Lin YS, Park J, De Schutter JW, Huang XF, Berghuis AM, Sebag M, et al. Design and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: Apoptosis and inhibition of ERK phosphorylation in multiple myeloma cells. Journal of Medicinal Chemistry. 2012;55(7):3201-15.

 

67. Park J, Lin YS, De Schutter JW, Tsantrizos YS, Berghuis AM. Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure. BMC Structural Biology. 2012;12.

 

68. Shi K, Berghuis AM. Structural basis for dual nucleotide selectivity of aminoglycoside 2''-phosphotransferase IVa provides insight on determinants of nucleotide specificity of aminoglycoside kinases. The Journal of biological chemistry. 2012 Apr 13;287(16):13094-102. PubMed PMID: 22371504. Pubmed Central PMCID: PMC3339986. Epub 2012/03/01. eng.

 

69. Yachnin BJ, Sprules T, McEvoy MB, Lau PC, Berghuis AM. The substrate-bound crystal structure of a Baeyer-Villiger monooxygenase exhibits a Criegee-like conformation. J Am Chem Soc. 2012 May 9;134(18):7788-95. PubMed PMID: 22506764. Pubmed Central PMCID: PMC3349289. Epub 2012/04/18. eng.

 

70. Cheung YH, Gayden T, Campeau PM, Leduc CA, Russo D, Nguyen VH, et al. A recurrent PDGFRB mutation causes familial infantile myofibromatosis. American Journal of Human Genetics. 2013;92(6):996-1000.

 

71. Leung CY, Park J, De Schutter JW, Sebag M, Berghuis AM, Tsantrizos YS. Thienopyrimidine bisphosphonate (ThPBP) inhibitors of the human farnesyl pyrophosphate synthase: Optimization and characterization of the mode of inhibition. Journal of Medicinal Chemistry. 2013;56(20):7939-50.

 

72. Mirza IA, Burk DL, Xiong B, Iwaki H, Hasegawa Y, Grosse S, et al. Structural analysis of a novel cyclohexylamine oxidase from Brevibacterium oxydans IH-35A. PLoS One. 2013;8(3):e60072. PubMed PMID: 23555888. Pubmed Central PMCID: PMC3608611. Epub 2013/04/05. eng.

 

73. Mui MZ, Kucharski M, Miron MJ, Hur WS, Berghuis AM, Blanchette P, et al. Identification of the adenovirus E4orf4 protein binding site on the B55alpha and Cdc55 regulatory subunits of PP2A: Implications for PP2A function, tumor cell killing and viral replication. PLoS Pathog. 2013;9(11):e1003742. PubMed PMID: 24244166. Pubmed Central PMCID: PMC3828177. Epub 2013/11/19. eng.

 

74. Shi K, Caldwell SJ, Fong DH, Berghuis AM. Prospects for circumventing aminoglycoside kinase mediated antibiotic resistance. Frontiers in Cellular and Infection Microbiology. 2013;4(JUN).

 

75. De Schutter JW, Park J, Leung CY, Gormley P, Lin YS, Hu Z, et al. Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: Implications to drug discovery for neurodegenerative diseases. Journal of Medicinal Chemistry. 2014;57(13):5764-76.

 

76. Freiburger L, Miletti T, Zhu S, Baettig O, Berghuis A, Auclair K, et al. Substrate-dependent switching of the allosteric binding mechanism of a dimeric enzyme. Nature chemical biology. 2014;10(11):937-42.

 

77. Gobeil SM, Clouthier CM, Park J, Gagne D, Berghuis AM, Doucet N, et al. Maintenance of native-like protein dynamics may not be required for engineering functional proteins. Chemistry & biology. 2014 Oct 23;21(10):1330-40. PubMed PMID: 25200606. Epub 2014/09/10. eng.

 

78. Lee MJ, Gravelat FN, Cerone RP, Baptista SD, Campoli PV, Choe SI, et al. Overlapping and distinct roles of Aspergillus fumigatus UDP-glucose 4-epimerases in galactose metabolism and the synthesis of galactose-containing cell wall polysaccharides. The Journal of biological chemistry. 2014 Jan 17;289(3):1243-56. PubMed PMID: 24257745. Pubmed Central PMCID: PMC3894311. Epub 2013/11/22. eng.

 

79. Park J, Lin YS, Tsantrizos YS, Berghuis AM. Structure of human farnesyl pyrophosphate synthase in complex with an aminopyridine bisphosphonate and two molecules of inorganic phosphate. Acta Crystallographica Section F:Structural Biology Communications. 2014;70(3):299-304.

 

80. Park J, Matralis AN, Berghuis AM, Tsantrizos YS. Human isoprenoid synthase enzymes as therapeutic targets. Frontiers in chemistry. 2014;2:50. PubMed PMID: 25101260. Pubmed Central PMCID: PMC4106277. Epub 2014/08/08. eng.

 

81. Salem S, Langlais D, Lefebvre F, Bourque G, Bigley V, Haniffa M, et al. Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8K108Emutation. Blood. 2014;124(12):1894-904.

 

82. Yachnin BJ, McEvoy MB, Maccuish RJD, Morley KL, Lau PCK, Berghuis AM. Lactone-bound structures of cyclohexanone monooxygenase provide insight into the stereochemistry of catalysis. ACS Chemical Biology. 2014;9(12):2843-51.

 

83. Bernatchez JA, Paul R, Tchesnokov EP, Ngure M, Beilhartz GL, Berghuis AM, et al. Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase. Journal of Biological Chemistry. 2015;290(3):1474-84.

 

84. Brannon JR, Burk DL, Leclerc JM, Thomassin JL, Portt A, Berghuis AM, et al. Inhibition of outer membrane proteases of the omptin family by aprotinin. Infection and immunity. 2015 Jun;83(6):2300-11. PubMed PMID: 25824836. Pubmed Central PMCID: PMC4432765. Epub 2015/04/01. eng.

 

85. Gritzalis D, Park J, Chiu W, Cho H, Lin YS, De Schutter JW, et al. Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase. Bioorganic & medicinal chemistry letters. 2015 Mar 1;25(5):1117-23. PubMed PMID: 25630225. Epub 2015/01/30. eng.